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Cimetidine, 51481-61-9, Acibilin manufacturer / supplier in China, offering Cimetidine (CAS 51481-61-9) From China Factory, Bicalutamide with High Quality From Chinaese Supplier CAS 90357-06-5, Oxygen-Fluorine Acid (CAS 82419-35-0) From China Factory and so on.

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Cimetidine (CAS 51481-61-9) From China Factory

FOB Price: Get Latest Price
Min. Order: 25 kg
Port: Shanghai, China
Transport Package: 25kg/Drum
Payment Terms: L/C, T/T, Western Union

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Basic Info
  • Model NO.: 51481-61-9
  • Trademark: EVERGREEN
  • Origin: China
  • CAS: 51481-61-9
  • Specification: 99%
Product Description
Product Name:Cimetidine
Synonyms:TAGAMET;SKF-92334;N-CYANO-N'-METHYL-N''-[[2-[(5-METHYL-1H-IMIDAZOL-4-YL)METHYL]THIO]ETHYL]GUANIDINE;Acibilin;Acinil;Cimal;Cimetag;Cimetum
CAS:51481-61-9
MF:C10H16N6S
MW:252.34
EINECS:257-232-2
Product Categories:Active Pharmaceutical Ingredients;Heterocycles;API intermediates;Intermediates & Fine Chemicals;Pharmaceuticals;Histamine receptor;MAXIPIME;Other APIs;API
Mol File:51481-61-9.mol
 
 
Cimetidine Chemical Properties
Melting point 139-144°C
storage temp. 2-8°C
Water Solubility 0.5 g/100 mL at 20 ºC
Merck 2279
CAS DataBase Reference51481-61-9(CAS DataBase Reference)
NIST Chemistry ReferenceCimetidine(51481-61-9)
EPA Substance Registry SystemGuanidine, N-cyano-N'-methyl-N''-[ 2-[[(5-methyl-1H-imidazol- 4-yl)methyl]thio]ethyl]-(51481-61-9)
 
Safety Information
Hazard Codes T,Xn
Risk Statements 60-42/43-36/37/38-20/22
Safety Statements 53-26-36/37/39-45-36-22
WGK Germany 3
RTECS MF0035500
Hazardous Substances Data51481-61-9(Hazardous Substances Data)
 
MSDS Information
ProviderLanguage
2-Cyano-1-methyl-3-(2-(((5-methylimidazol-4-yl)methyl)thio)ethyl)guanidineEnglish
SigmaAldrichEnglish
 
Cimetidine Usage And Synthesis
DescriptionCimetidine (brand name: Tagamet) is a kind of histamine H2 receptor antagonist being capable of inhibiting the production of stomach acid, which reduces the gastric volume and acidity. It is mainly used for the treatment of heartburn and peptic ulcers. There are also evidences that it can be used for the treatment of common warts, chronic calcific tendinitis of the shoulder, and even colorectal cancer. It is capable of not only inhibiting the gastric acid secretion, as well as pepsin and gastrins output, but also inhibiting the activity of cytochrome P450. It reduces the gastric acid secretion through binding to the H2 receptor locating on the basolateral membrane of the gastric parietal cell, and further blocking histamine effect.
Referenceshttps://www.drugbank.ca/drugs/DB00501
https://en.wikipedia.org/wiki/Cimetidine
Chemical PropertiesWhite Solid
Usesantibacterial
UsesCompetitive histamine H2-receptor antagonist which inhibits gastric acid secretion and reduces pepsin output
DefinitionChEBI: A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H -receptor antagonist that inhibits the production of acid in stomach.
General DescriptionWhite crystals with a slight sulfur-mercaptan odor.
Air & Water ReactionsSlightly water soluble.
Fire HazardFlash point data for Cimetidine are not available. Cimetidine is probably combustible.
Biological ActivityWidely used H 2 histamine antagonist which has more recently been described as an inverse agonist. Also a potent I 1 imidazoline binding site ligand.
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