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Hefei Evergreen Chemical Industry Co., Ltd.

Regorafenib, 755037-03-7, API manufacturer / supplier in China, offering 99.0% Purity Pharmaceutical Raw Materials Regorafenib (CAS 755037-03-7), 99.0% Purity 1, 2-Hexanediol (CAS 6920-22-5), Sugar Substitute Sorbitol 70% Solution CAS 50-70-4 and so on.

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99.0% Purity Pharmaceutical Raw Materials Regorafenib (CAS 755037-03-7)

FOB Price: Get Latest Price
Min. Order: 1 kg
Port: Shanghai, China
Transport Package: 1kg/Tin
Payment Terms: L/C, T/T, Western Union

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Basic Info
  • Model NO.: 755037-03-7
  • Customized: Non-Customized
  • Suitable for: Elderly, Children, Adult
  • Purity: >99%
  • Specification: 1KG/TIN, 99.0%, Enterprise standard
  • HS Code: 29339900
  • Powder: Yes
  • Certification: Enterprise Standard
  • State: Solid
  • Trademark: EVERGREEN
  • Origin: Anhui China
Product Description
Product Name: Regorafenib
Chemical Name:4-[4-({[4-Chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide
CAS NO.: 755037-03-7
Molecular Formula:C21H15ClF4N4O3
Formula Weight:482.815
Structural formula:
        99.0% Purity Pharmaceutical Raw Materials Regorafenib (CAS 755037-03-7)
Appearance: White crystalline powder.
Density: 1.491 g/cm3
Boiling point:513.4 ºC at 760 mmHg
Flash point: 264.3 ºC
Quality Specification:
Enterprise standard,≥99.0%
Item of analysisStandardResult of analysis
DescriptionWhite to pink crystalline powderWhite crystalline powder
IdentificationHPLCConsistent retention time
Water content≤1.0%0.16%
Sulphated ash≤0.5%Complies
Ordinary impuritiessingle impurity ≤ 0.5%0.08%
total impurities ≤1.0%0.1%
purity (HPLC)≥99%99.9%
Conclusion:Conform In-house standard.
1.It inhibits PDGFR tyrosine kinase with IC50=83nM. And it is useful for the treatment of inflammation and as an anti-proliferative agent.
2.Regorafenib is a multikinase inhibitor with IC50 of 17, 40 and 69 nM c-KIT, VEGFR2, B-Raf.
3.Regorafenib is a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3, PDGFRβ, Kit, RET and Raf-1 with IC50 of 13 nM/4.2 nM/46 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM, respectively.

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