EP 97% Purity Granisetron Hydrochloride (CAS 107007-99-8)
|FOB Price:||Get Latest Price|
|Min. Order:||5 kg|
|Transport Package:||5kg/Aluminum Can|
|Payment Terms:||L/C, T/T, Western Union|
- Model NO.: 107007-99-8
- Customized: Non-Customized
- Suitable for: Elderly, Children, Adult
- Purity: >97%
- Specification: 5kg/aluminum can, EP, 97%
- HS Code: 29329990
- Powder: Yes
- Certification: USP, BP
- State: Solid
- Trademark: EVERGREEN
- Origin: Anhui China
CAS NO.: 107007-99-8
Appearance: white or yellowish white crystalline powder and is odorless.
Solubility: Easily soluble in water but hardly soluble in methanol, extremely hardly to be dissolved in ethanol and almost insoluble in ether.
It has a melting point of 290-292 ºC. For acute toxicity LD50, female mice, male and female rats (mg/kg): 17, 25, 14, 16, respectively. Intravenous injection.
Quality Specification: EP8.1, ≥97%
|Test items||Quality requirements||Results|
|Apperance||White or almost white powder||Complies|
|Solubility||Freely soluble in water, sparingly soluble in methylene chloride, slightly soluble in methanol.||Complies|
|(a)||Infrared absorption spectrophotometry (2.2.24).|
Comparison granisetron hydrochloride CRS.
|(b)||It gives reaction (a) of chlorides(2.3.1).||Complies|
|(a) Solution S||Dissolve 0.2 g in carbon dioxide free water|
R and dilute to 20 ml with the same solvent.
|(b)Apperance||Solution S is clear (2.2.1) and colourless (2.2.2, Method II).||Complies|
|(d)Relative substances||Total ≤1.0%||0.10%|
|any other impurity≤0.1%||Complies|
|(g)Loss on drying||≤0.5 %||0.1%|
|(h) Residual solvents||methanol ≤0.3%||0.07%|
|dichloromethane ≤0.06%||Not detected|
|Microbial limits||Molds and yeasts<50cfu/g||<10cfu/g|
|Staphylococcus aureus||Not detected|
|CONCLUSION: ACCORDANCE WITH THE REFERENCE|
Anticoagulant.A specific serotonin (5HT3) receptor antagonist. Used as an antiemetic. Granisetron HCl is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemothera py. Its main effect is to reduce the activity of the vagus nerve. It does not have much effect on vomiting due to motion sickness.
Packaging: 5kg/aluminum can.