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Granisetron Hydrochloride, 107007-99-8, Gransetron HCl manufacturer / supplier in China, offering EP 97% Purity Granisetron Hydrochloride (CAS 107007-99-8), 2, 4-Dichloro-3, 5-Dimethylphenol Dcmx CAS: 133-53-9, Diminazene Aceturate and so on.

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EP 97% Purity Granisetron Hydrochloride (CAS 107007-99-8)

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Min. Order: 5 kg
Port: Shanghai, China
Transport Package: 5kg/Aluminum Can
Payment Terms: L/C, T/T, Western Union
Powder: Yes
Customized: Non-Customized
Certification: USP, BP
Suitable for: Elderly, Children, Adult
State: Solid
Purity: >97%

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Basic Info

Model NO.: 107007-99-8
Trademark: EVERGREEN
Specification: 5kg/aluminum can, EP, 97%
Origin: Anhui China
HS Code: 29329990

Product Description

Product Name: Granisetron hydrochloride
Chemical Name:1-methyl-n-(9-methyl-9-azabicyclo(3.3.1)non-3-yl)-1h-indazole-3-carboxamid
CAS NO.: 107007-99-8
Molecular Formula:C18H25ClN4O
Formula Weight:348.87
Structural formula:
      EP 97% Purity Granisetron Hydrochloride (CAS 107007-99-8)
Properties:
Appearance: white or yellowish white crystalline powder and is odorless.
Solubility: Easily soluble in water but hardly soluble in methanol, extremely hardly to be dissolved in ethanol and almost insoluble in ether.
It has a melting point of 290-292 ºC. For acute toxicity LD50, female mice, male and female rats (mg/kg): 17, 25, 14, 16, respectively. Intravenous injection.

Quality Specification: EP8.1, 97%
Test itemsQuality requirementsResults
Characters
ApperanceWhite or almost white powderComplies
SolubilityFreely soluble in water, sparingly soluble in methylene chloride, slightly soluble in methanol.Complies
Identification
(a)Infrared absorption spectrophotometry (2.2.24).
Comparison granisetron hydrochloride CRS.
Complies
(b)It gives reaction (a) of chlorides(2.3.1).Complies
TESTS
(a) Solution SDissolve 0.2 g in carbon dioxide free water
R and dilute to 20 ml with the same solvent.
Complies
(b)ApperanceSolution S is clear (2.2.1) and colourless (2.2.2, Method II).Complies
(c)PH4.0~6.56.2
(d)Relative substancesTotal   ≤1.0%0.10%
Impurity A≤1.0%Complies
Impurity B≤0.5%Complies
Impurity C≤0.2%Complies
Impurity D≤0.1%Complies
Impurity E≤0.5%Complies
any other impurity≤0.1%Complies
(e)Heavy metals≤10ppm<10ppm
(f)Sulphated ash≤0.1%0.01%
(g)Loss on drying≤0.5 %0.1%
(h) Residual solventsmethanol ≤0.3%0.07%
dichloromethane ≤0.06%Not detected
Microbial limitsMolds and yeasts<50cfu/g<10cfu/g
E.coli<20cfu/g<10cfu/g
Staphylococcus aureusNot detected
Assay97%-102%100.7%
CONCLUSION: ACCORDANCE WITH THE REFERENCE
 
Application:
Anticoagulant.A specific serotonin (5HT3) receptor antagonist. Used as an antiemetic. Granisetron HCl is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemothera py. Its main effect is to reduce the activity of the vagus nerve. It does not have much effect on vomiting due to motion sickness.

Packaging: 5kg/aluminum can.

 

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